A Mathematical Model of Bisphenol A pharmocakinetics in the Mouse
By: Stephanie Abascal
Bisphenol A (BPA) is a chemical that is used in epoxy resins and a lot of plastic products ranging from baby bottles to the soda cans. This chemical is a threathening one when taken into the body as it causes health risks from sterilization to being a precursor to breast cancer.
There are mathematical equations namely, ODEs, that can model the levels of BPA in the body. These models are similar if not the same as those used in the SIR model that we studied in class. Abascal used Kawamoto's physiological based pharmacokinetic (PBPK) model which studies what the body of a human or mouse for example does to the BPA drug. This analysis inlcudes 27 equation which she cuts down to 3 and working with the equation that refers to the foetus and nondimensionalised it by dividing by some constant with the same units. This takes away the complexity making it easier to understand. BPa never leaves the body but accumulates.
This is bad as BPA can be found in baby bottles; directly affecting your baby.
Abascal made the final conclusion: BPA is bad! Keep the following in mind: The higher the number of the plastic, the harder it is and the harder it is the more likely is it to release BPA into whatever it holds. (The Macalester water bottles are made of a number 7 plastic!!!!)
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6 comments:
I have found my new Chem. tutor! lol
Sir Scribbs, don't kill me oh!
I had to leave my mark!
i am confuzzled with all the equations, i cant even keep up but i think i will take this point away
ok so the gist is. BPA= BAD
plastics=bad
probably why i shouldnt drink bottled water eh and switch to stainless steel water bottles...
CultureCynic, that really was the basic msg!
Lol @ your disclaimer up on top..
:/ Felt necessary after reading comments. *shrug* :)
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